Title : Deficiency of activating Fcγ-receptors reduces hepatic clearance and deposition of IC and increases CIC levels in mercury-induced autoimmunity.

Pub. Date : 2010 Oct 15

PMID : 20976163






2 Functional Relationships(s)
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1 METHODS AND PRINCIPAL FINDINGS: Mercury treated BALB/c wt mice showed a significant but modest increase of circulating IC (CIC) from day 12 until day 18 and day 35 for IgG2a- and IgG1- CIC, respectively. Mercury immunoglobulin heavy variable V1-9 Mus musculus
2 Mercury-treated mice lacking the trans-membrane gamma-chain of activating FcgammaRs (FcRgamma(-/-)) had significantly higher CIC levels of both IgG1-CIC and IgG2a-CIC than wt mice during the treatment course. Mercury immunoglobulin heavy variable V1-9 Mus musculus