Title : SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.

Pub. Date : 2010 Oct 21

PMID : 20975832






1 Functional Relationships(s)
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1 BACKGROUND: The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. NAD tumor protein p53 Homo sapiens