Title : Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

Pub. Date : 2011 Jan

PMID : 20974802






1 Functional Relationships(s)
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1 On the basis of a kinome-wide small interfering RNA (siRNA) screen and confirmative biochemical analysis, we show that several proline-directed mitogen-activated protein kinases (MAPKs), such as p38, ERK1/2, and JNK1 are sufficient and required for the phosphorylation of PPPS/TP motifs of LRP6. Proline mitogen-activated protein kinase 1 Homo sapiens