Pub. Date : 2011 Feb
PMID : 20965247
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type beta receptors and the JNK pathway. | lysophosphatidic acid | cellular communication network factor 2 | Homo sapiens |
| 2 | We decided to evaluate the effect of LPA together with TGF-beta on CTGF expression. | lysophosphatidic acid | cellular communication network factor 2 | Homo sapiens |
| 3 | We found that myoblasts treated with LPA and TGF-beta1 produced an additive effect on CTGF expression. | lysophosphatidic acid | cellular communication network factor 2 | Homo sapiens |
| 4 | In the absence of TGF-beta, the induction of CTGF expression by LPA was abolished by a dominant negative form of the TGF-beta receptor type II (TGF-betaRII) and by the use of SB 431542, a specific inhibitor of the serine/threonine kinase activity of TGF-betaRI, suggesting that CTGF induction is dependent on LPA and requires active TGF-betaRs. | lysophosphatidic acid | cellular communication network factor 2 | Homo sapiens |
| 5 | In the absence of TGF-beta, the induction of CTGF expression by LPA was abolished by a dominant negative form of the TGF-beta receptor type II (TGF-betaRII) and by the use of SB 431542, a specific inhibitor of the serine/threonine kinase activity of TGF-betaRI, suggesting that CTGF induction is dependent on LPA and requires active TGF-betaRs. | lysophosphatidic acid | cellular communication network factor 2 | Homo sapiens |
| 6 | In the absence of TGF-beta, the induction of CTGF expression by LPA was abolished by a dominant negative form of the TGF-beta receptor type II (TGF-betaRII) and by the use of SB 431542, a specific inhibitor of the serine/threonine kinase activity of TGF-betaRI, suggesting that CTGF induction is dependent on LPA and requires active TGF-betaRs. | lysophosphatidic acid | cellular communication network factor 2 | Homo sapiens |
| 7 | Finally, we demonstrated that CTGF induction in response to LPA requires the activation of JNK, but not ERK, signaling pathways. | lysophosphatidic acid | cellular communication network factor 2 | Homo sapiens |