Title : Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways.

Pub. Date : 2011 Jan 10

PMID : 20965163






3 Functional Relationships(s)
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1 Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
2 Mechanistically, honokiol suppressed H(2)O(2)-induced phosphorylation of ERK1/2, p38 mitogen-activated protein kinase (MAPK), JNK and Akt. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
3 These results demonstrate that honokiol suppresses H(2)O(2)-induced HLE cell apoptosis via interference with the MAPKs, Akt and NF-kappaB signaling, suggesting that honokiol might have a potential effect against cataract formation. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens