Title : Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action.

Pub. Date : 2010 Dec

PMID : 20963488






2 Functional Relationships(s)
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1 Furthermore, bufalin inhibited the protein expressions and phosphorylation of Akt, NF-kappaB, p44/42 MAPK (ERK1/2) and p38 MAPK in A549 cells. bufalin interferon induced protein 44 Homo sapiens
2 Our results suggest that bufalin inhibits the human lung cancer cell proliferation via VEGFR1/VEGFR2/EGFR/c-Met-Akt/p44/42/p38-NF-kappaB signaling pathways; bufalin may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of human NSCLC. bufalin interferon induced protein 44 Homo sapiens