Title : Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD.

Pub. Date : 2010 Nov 12

PMID : 20946880






2 Functional Relationships(s)
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1 In the present investigation, we analyzed whether treatment with rosuvastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, would prevent the increases in inflammatory microglia and IL-6 levels in the brain and plasma of WT and ApoE-/- mice. Rosuvastatin Calcium interleukin 6 Mus musculus
2 Rosuvastatin treatment resulted in lowered plasma IL-6 levels in WT mice on a HC diet. Rosuvastatin Calcium interleukin 6 Mus musculus