Pub. Date : 2010 Nov 12
PMID : 20946880
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD. | Rosuvastatin Calcium | apolipoprotein E | Mus musculus |
| 2 | In the present investigation, we analyzed whether treatment with rosuvastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, would prevent the increases in inflammatory microglia and IL-6 levels in the brain and plasma of WT and ApoE-/- mice. | Rosuvastatin Calcium | apolipoprotein E | Mus musculus |
| 3 | Treatment with rosuvastatin significantly decreased the microglia load in the brains of WT and ApoE-/- mice on a HC diet. | Rosuvastatin Calcium | apolipoprotein E | Mus musculus |