Title : Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors.

Pub. Date : 2011 Jan

PMID : 20946088






2 Functional Relationships(s)
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1 In contrast, NTCP*2 displayed greater transport of atorvastatin and rosuvastatin, compared with NTCP wild type. Rosuvastatin Calcium solute carrier family 10 member 1 Homo sapiens
2 Thus, the measurements of decreased rosuvastatin and atorvastatin transport by OATP1B1*15 were confounded by the presence of NTCP and its genetic variant, NTCP*2. Rosuvastatin Calcium solute carrier family 10 member 1 Homo sapiens