Title : Caveolin-1 and doxorubicin-induced P-glycoprotein modulate plasma cholesterol membrane accessibility in erythrolymphoblastic cell line.

Pub. Date : 2010 Sep

PMID : 20944122






6 Functional Relationships(s)
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1 Caveolin-1 and doxorubicin-induced P-glycoprotein modulate plasma cholesterol membrane accessibility in erythrolymphoblastic cell line. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
2 UNLABELLED: AIM/ BACKGROUND: Various interactions between Caveolae membrane domains, multidrug resistance transporter P-glycoprotein (P-gp) and cholesterol have been suggested. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
3 UNLABELLED: AIM/ BACKGROUND: Various interactions between Caveolae membrane domains, multidrug resistance transporter P-glycoprotein (P-gp) and cholesterol have been suggested. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
4 We tested the assumption that anthracycline-induced P-gp and Caveolin-1 have correlated effects on cholesterol distribution in plasma membrane. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
5 CONCLUSION: Combination of functional P-gp, caveolae presence and lasting effect of anthracycline treatment appear determinant in free membrane cholesterol homeostasis and likely modulate cholesterol membrane order. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
6 CONCLUSION: Combination of functional P-gp, caveolae presence and lasting effect of anthracycline treatment appear determinant in free membrane cholesterol homeostasis and likely modulate cholesterol membrane order. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens