Title : α4β2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling.

Pub. Date : 2011 Jan

PMID : 20943775






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We reported previously that nicotine suppresses constitutive nuclear factor kappaB (NF-kappaB) activity and thereby proinflammatory cytokine (PIC) production in SHEP1 cells stably transfected with alpha4beta2 nicotinic receptors. Nicotine nuclear factor kappa B subunit 1 Homo sapiens
2 Nicotine (100-300 nM, concentrations found in smoker"s blood) blocked LPS-induced NF-kappaB translocation and production of PICs interleukin (IL)-1beta and IL-6 but only partially blocked inhibitor of nuclear factor-kappaBalpha (IkappaBalpha) phosphorylation. Nicotine nuclear factor kappa B subunit 1 Homo sapiens
3 However, the effects of nicotine on NF-kappaB activity were significantly blocked by the highly specific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the signal transducer and activator of transcription 3 (STAT3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859). Nicotine nuclear factor kappa B subunit 1 Homo sapiens