Pub. Date : 2011 Mar
PMID : 20941644
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we demonstrate that intranasal administration of phosphoramidon produces significantly elevated cerebral Abeta levels in wild-type mice. | phosphoramidon | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | Furthermore, intranasal phosphoramidon administration in double knockout mice lacking NEP and NEP2 also showed increased levels of Abeta(40). | phosphoramidon | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | These data show that intranasal delivery of drugs can be used to model AD and suggest that other phosphoramidon-sensitive peptidases are degrading Abeta in NEP/NEP2-deficient mice. | phosphoramidon | amyloid beta (A4) precursor protein | Mus musculus |