Pub. Date : 2011 Jan 15
PMID : 20940012
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | eNOS/Hsp70 interaction on rosuvastatin cytoprotective effect in neonatal obstructive nephropathy. | Rosuvastatin Calcium | nitric oxide synthase 3 | Rattus norvegicus |
| 2 | Here we determined whether eNOS associated with Hsp70 expression is involved in rosuvastatin resistance to obstruction-induced oxidative stress and cell death. | Rosuvastatin Calcium | nitric oxide synthase 3 | Rattus norvegicus |
| 3 | Conversely, in cortex membrane fractions from rosuvastatin-treated UUO rats, marked upregulation of eNOS expression at transcriptional and posttranscriptional levels linked to increased Hsf1 mRNA expression and enhanced mRNA and protein Hsp70 expression, were observed. | Rosuvastatin Calcium | nitric oxide synthase 3 | Rattus norvegicus |
| 4 | In addition, interaction between eNOS and Hsp70 was determined by communoprecipitation in cortex membrane fractions, showing an increased ratio of both proteins, after rosuvastatin treatment in obstructed kidney. | Rosuvastatin Calcium | nitric oxide synthase 3 | Rattus norvegicus |
| 5 | In summary, our data demonstrate that the effect of rosuvastatin on eNOS interacting with Hsp70, results in the capacity of both to prevent mitochondrial apoptotic pathway and oxidative stress in neonatal early kidney obstruction. | Rosuvastatin Calcium | nitric oxide synthase 3 | Rattus norvegicus |