Pub. Date : 2010 Nov 15
PMID : 20939553
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation. | nimesulide | myeloperoxidase | Homo sapiens |
| 2 | We demonstrate here that the reduced nimesulide, M1, undergoes a facile oxidation with activated neutrophils or with MPO in the presence of H(2)O(2) or HOCl to produce a variety of reactive as well as stable metabolites. | nimesulide | myeloperoxidase | Homo sapiens |
| 3 | Other metabolites, for example, M6, M8, and M9, were unique to the myeloperoxidase, because of their mode of formation from activation of the amino group of reduced nimesulide. | nimesulide | myeloperoxidase | Homo sapiens |
| 4 | In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. | nimesulide | myeloperoxidase | Homo sapiens |
| 5 | In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. | nimesulide | myeloperoxidase | Homo sapiens |
| 6 | In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. | nimesulide | myeloperoxidase | Homo sapiens |
| 7 | In summary, our results demonstrate that a known nimesulide metabolite could be bioactivated by MPO through a pathway distinct from HLM-mediated pathways and that the generation of reactive species by the MPO-mediated bioactivation pathway at the site of inflammation may contribute to the toxicity associated with nimesulide. | nimesulide | myeloperoxidase | Homo sapiens |