Pub. Date : 2012 Feb
PMID : 20938793
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro. | Diphosphonates | TNF superfamily member 11 | Homo sapiens |
| 2 | The objective of this study was to evaluate the effect of bisphosphonates on the gene expression of receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG) in vitro. | Diphosphonates | TNF superfamily member 11 | Homo sapiens |
| 3 | The objective of this study was to evaluate the effect of bisphosphonates on the gene expression of receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG) in vitro. | Diphosphonates | TNF superfamily member 11 | Homo sapiens |
| 4 | The results showed a moderate enhancement of OPG gene expression whereas RANKL gene expression was strongly increased by nitrogen-containing bisphosphonates reaching a maximum after 14 days at high concentrations of 5 x 10(-5) M. Lower concentrations did not enhance the RANKL and OPG expression considerably. | Diphosphonates | TNF superfamily member 11 | Homo sapiens |
| 5 | The non-nitrogen-containing bisphosphonate clodronate, however, effected OPG and RANKL gene expression much less, even at higher concentrations of 5 x 10(-3) M. The above-mentioned data suggest an enhanced RANKL/OPG gene expression after stimulation by bisphosphonates. | Diphosphonates | TNF superfamily member 11 | Homo sapiens |
| 6 | The non-nitrogen-containing bisphosphonate clodronate, however, effected OPG and RANKL gene expression much less, even at higher concentrations of 5 x 10(-3) M. The above-mentioned data suggest an enhanced RANKL/OPG gene expression after stimulation by bisphosphonates. | Diphosphonates | TNF superfamily member 11 | Homo sapiens |
| 7 | The non-nitrogen-containing bisphosphonate clodronate, however, effected OPG and RANKL gene expression much less, even at higher concentrations of 5 x 10(-3) M. The above-mentioned data suggest an enhanced RANKL/OPG gene expression after stimulation by bisphosphonates. | Diphosphonates | TNF superfamily member 11 | Homo sapiens |