Pub. Date : 2010 Dec 15
PMID : 20937379
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress. | Paraquat | catalase | Mus musculus |
| 2 | This study examined the influence of cardiac-specific overexpression of catalase, an antioxidant detoxifying H(2)O(2), on paraquat-induced myocardial geometric and functional alterations, with a focus on ER stress. | Paraquat | catalase | Mus musculus |
| 3 | Whereas the catalase transgene itself did not alter myocardial geometry and function, it mitigated or significantly attenuated paraquat-elicited myocardial geometric and functional changes. | Paraquat | catalase | Mus musculus |
| 4 | Paraquat promoted overt apoptosis and ER stress as evidenced by increased caspase-3 activity, apoptosis, and ER stress markers including Bax, Bcl-2, GADD153, calregulin, and phosphorylated JNK, IRE1alpha, and eIF2alpha; all were ablated by the catalase transgene. | Paraquat | catalase | Mus musculus |
| 5 | Taken together, these data revealed that catalase may rescue paraquat-induced myocardial geometric and functional alteration possibly by alleviating JNK-mediated ER stress. | Paraquat | catalase | Mus musculus |