Title : In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies.

Pub. Date : 2010 Nov

PMID : 20937004






3 Functional Relationships(s)
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1 AZD2624 exhibited an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC(50) values of 7.1 and 19.8 microM for midazolam and testosterone assays, respectively. 3-((methylsulfonyl)amino)-2-phenyl-N-(1-phenylpropyl)quinolin-4-carboxamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Although AZD2624-induced CYP3A4 activity in hepatocytes, the potential of AZD2624 to cause inductive drug interactions of this enzyme was low at relevant exposure concentration. 3-((methylsulfonyl)amino)-2-phenyl-N-(1-phenylpropyl)quinolin-4-carboxamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 However, metabolism of AZD2624 might be inhibited when co-administrated with potent CYP3A4/5 inhibitors. 3-((methylsulfonyl)amino)-2-phenyl-N-(1-phenylpropyl)quinolin-4-carboxamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens