Pub. Date : 2011 Jan
PMID : 20936632
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CCN2 is required for bleomycin-induced skin fibrosis in mice. | Bleomycin | cellular communication network factor 2 | Mus musculus |
| 2 | The aim of this study was to assess whether adult mice bearing a smooth muscle cell/fibroblast-specific deletion of CCN2 are resistant to bleomycin-induced skin scleroderma. | Bleomycin | cellular communication network factor 2 | Mus musculus |
| 3 | RESULTS: The loss of CCN2 resulted in resistance to bleomycin-induced skin fibrosis. | Bleomycin | cellular communication network factor 2 | Mus musculus |
| 4 | Collectively, these results indicate that CCN2 is essential for bleomycin-induced skin fibrosis, likely due to a defect in myofibroblast recruitment. | Bleomycin | cellular communication network factor 2 | Mus musculus |