Pub. Date : 2010 Dec 1
PMID : 20935474
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers. | Topotecan | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | RESULTS: Topotecan significantly inhibited Cisplatin-induced Akt activation in Caov-3 cells, but not in A2780 cells. | Topotecan | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Topotecan inhibited not only Cisplatin-induced Akt activation but also VEGF and HIF-1alpha expression. | Topotecan | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | CONCLUSION: We herein demonstrated that Topotecan inhibits Akt kinase activity and VEGF transcriptional activation after Cisplatin treatment in platinum-resistant ovarian cancers. | Topotecan | AKT serine/threonine kinase 1 | Homo sapiens |