Title : Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene.

Pub. Date : 2011 Jan 15

PMID : 20933534






3 Functional Relationships(s)
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1 Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene. esculetin NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 Moreover, treatment with 25 muM esculetin for 8h increased the expression of NAD(P)H: quinone oxidoreductase (NQO1) at both protein and mRNA levels significantly, by 12-fold and 15-fold, respectively. esculetin NAD(P)H quinone dehydrogenase 1 Homo sapiens
3 Esculetin treatment also increased nuclear accumulation of Nrf2 by 8-fold indicating that increased NQO1 expression is Nrf2-mediated. esculetin NAD(P)H quinone dehydrogenase 1 Homo sapiens