Title : CWJ-081, a novel 3-arylisoquinoline derivative, induces apoptosis in human leukemia HL-60 cells partially involves reactive oxygen species through c-Jun NH2-terminal kinase pathway.

Pub. Date : 2010 Nov 15

PMID : 20932751






1 Functional Relationships(s)
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1 Taken together, these data suggest that CWJ-081 induces apoptosis via the mitochondrial apoptotic pathway in HL-60 cells, and ROS-mediated JNK activation plays a key role in the CWJ-081-induced apoptosis. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens