Pub. Date : 2010 Oct
PMID : 20930594
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using patch clamp recording in human stem cell-derived cardiomyocytes and stably transfected mammalian cells, we found that methadone produced concentration-dependent AP prolongation and ion channel block at low micromolar concentrations: hERG (IC50 = 1.7 muM), hNav1.5 (11.2 muM tonic block; 5.5 muM phasic block), and hCav1.2 (26.7 muM tonic block; 7.7 muM phasic block). | Methadone | ETS transcription factor ERG | Homo sapiens |
| 2 | Thus, although diazepam alone does not prolong the QT interval, the relief of methadone-induced Na channel block may leave hERG K channel block uncompensated, thereby increasing cardiac risk. | Methadone | ETS transcription factor ERG | Homo sapiens |