Title : Decoding the intrinsic mechanism that prohibits ALIX interaction with ESCRT and viral proteins.

Pub. Date : 2010 Dec 15

PMID : 20929444






2 Functional Relationships(s)
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1 Our results demonstrate that an intramolecular interaction between Patch 2 in the Bro1 domain and the TSG101 (tumour susceptibility gene 101 protein)-docking site in the proline-rich domain locks ALIX into a closed conformation that renders ALIX unable to interact with CHMP4 and retroviral Gag proteins. Proline programmed cell death 6 interacting protein Homo sapiens
2 Our results demonstrate that an intramolecular interaction between Patch 2 in the Bro1 domain and the TSG101 (tumour susceptibility gene 101 protein)-docking site in the proline-rich domain locks ALIX into a closed conformation that renders ALIX unable to interact with CHMP4 and retroviral Gag proteins. Proline programmed cell death 6 interacting protein Homo sapiens