Title : Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women.

Pub. Date : 2010 Dec

PMID : 20924570






1 Functional Relationships(s)
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1 PURPOSE: To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens