Pub. Date : 2010 Nov 26
PMID : 20921230
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have characterized the PIP(2) dependence of purified human Kir2.1 and Kir2.2 activity using (86)Rb(+) flux and patch clamp assays in liposomes of defined composition. | Phosphatidylinositol 4,5-Diphosphate | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 2 | The results provide the first quantitative description of the dependence of eukaryotic Kir channel function on PIP(2) levels in the membrane; Kir2.1 shows measureable activity in as little as 0.01% PIP(2), and open probability increases to ~0.4 at 1% PIP(2). | Phosphatidylinositol 4,5-Diphosphate | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 3 | Activation of Kir2.1 by phosphatidylinositol phosphates is also highly selective for PIP(2); PI, PI(4)P, and PI(5)P do not activate channels, and PI(3,4,5)P(3) causes minimal activity. | Phosphatidylinositol 4,5-Diphosphate | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |