Title : Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate.

Pub. Date : 2010 Nov 26

PMID : 20921230






2 Functional Relationships(s)
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1 The results provide the first quantitative description of the dependence of eukaryotic Kir channel function on PIP(2) levels in the membrane; Kir2.1 shows measureable activity in as little as 0.01% PIP(2), and open probability increases to ~0.4 at 1% PIP(2). Phosphatidylinositol 4,5-Diphosphate killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens
2 The PIP(2) dependence of eukaryotic Kir activity is almost exactly opposite that of KirBac1.1, which shows marked inhibition by PIP(2). Phosphatidylinositol 4,5-Diphosphate killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens