Title : Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.

Pub. Date : 2010 Dec 15

PMID : 20920557






1 Functional Relationships(s)
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1 The same results were obtained in the cells treated with N-acetyl-L-cysteine, suggesting that the prolonged activation of JNK and p38 by ISA is mediated by reactive oxygen species generated from mitochondria. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens