Pub. Date : 2010 Nov
PMID : 20886225
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nonetheless, beta-catenin-positive hepatocytes had no striking proliferative advantage, but started to grow out on treatment with phenobarbital, a tumor-promoting agent known to facilitate the formation of mouse liver adenoma with activating mutations of Ctnnb1. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 2 | Nonetheless, beta-catenin-positive hepatocytes had no striking proliferative advantage, but started to grow out on treatment with phenobarbital, a tumor-promoting agent known to facilitate the formation of mouse liver adenoma with activating mutations of Ctnnb1. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 3 | In summary, our data demonstrate that the zone-specificity of a hepatocyte"s gene expression profile is dependent on the presence of beta-catenin, and that beta-catenin provides a proliferative advantage to hepatocytes when promoted with phenobarbital, or in a pre-cirrhotic environment. | Phenobarbital | catenin (cadherin associated protein), beta 1 | Mus musculus |