Title : A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach.

Pub. Date : 2010 Sep 23

PMID : 20886100






2 Functional Relationships(s)
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1 Five independent selections revealed related mutations in a single dipeptide motif (D316 and Y317) located in a proline-rich region of NS5A domain II, which has been implicated in CyPA binding. Proline peptidylprolyl isomerase A Homo sapiens
2 Engineering the mutations into wild-type HCV fully recapitulated the CyPA-independent and CsA-resistant phenotype and four putative proline substrates of CyPA were mapped to the vicinity of the DY motif. Proline peptidylprolyl isomerase A Homo sapiens