Title : Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism.

Pub. Date : 2011 Mar

PMID : 20883815






1 Functional Relationships(s)
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1 Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin. Curcumin mitochondrially encoded cytochrome c oxidase II Homo sapiens