Title : Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.

Pub. Date : 2010 Dec 24

PMID : 20880848






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TMZ-induced O(6)-methylguanine production is involved in AMPK activation. O-(6)-methylguanine protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 O(6)-benzylguanine, an O(6)-methylguanine-DNA methyltransferase inhibitor, enhances TMZ-induced O(6)-methylguanine production, leading to enhanced reactive oxygen species production, which serves as an upstream signal for AMPK activation. O-(6)-methylguanine protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens