Pub. Date : 2010 Nov
PMID : 20878066
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | In this report, using a cell line with knock-down p53 expression through siRNA, we found that amifostine enhancement of paclitaxel"s anticancer effect is p53 status-dependent. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | In this report, using a cell line with knock-down p53 expression through siRNA, we found that amifostine enhancement of paclitaxel"s anticancer effect is p53 status-dependent. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 4 | Sensitivity to the therapeutic effect of paclitaxel in combination with amifostine was dependent upon the status of p53. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 5 | A tumor with a nonsense TP53 mutation showed increased therapeutic response to paclitaxel and amifostine as measured by tumor weight compared to a tumor with wild- type TP53. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 6 | Our study provides a rationale for a clinical trial of combined paclitaxel and amifostine in endometrial cancer patients whose tumors harbor TP53 mutations. | Paclitaxel | tumor protein p53 | Homo sapiens |