Title : Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.

Pub. Date : 2010 Sep 22

PMID : 20877636






2 Functional Relationships(s)
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1 Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain. Serine Cbl proto-oncogene Homo sapiens
2 This obvious reduction in binding affinity, however, indicates that Cbl"s interactions with its TKB-centered binding partners may be more favorable in the absence of Ser/Thr phosphorylation, which is stimulation and context specific in vivo. Serine Cbl proto-oncogene Homo sapiens