Title : The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes.

Pub. Date : 2011 Apr

PMID : 20875690






5 Functional Relationships(s)
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1 Antimycotics itraconazole and terbinafine hydrochloride increased hBD-3 secretion and mRNA levels in parallel to the enhanced activity of activator protein-1, expression and phosphorylation of activator protein-1 component, c-Fos, but fluconazole was ineffective. Itraconazole Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Antimycotics itraconazole and terbinafine hydrochloride increased hBD-3 secretion and mRNA levels in parallel to the enhanced activity of activator protein-1, expression and phosphorylation of activator protein-1 component, c-Fos, but fluconazole was ineffective. Itraconazole Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Antimycotics itraconazole and terbinafine hydrochloride increased hBD-3 secretion and mRNA levels in parallel to the enhanced activity of activator protein-1, expression and phosphorylation of activator protein-1 component, c-Fos, but fluconazole was ineffective. Itraconazole Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 These results suggest that itraconazole and terbinafine hydrochloride may enhance c-Fos expression and phosphorylation, activator protein-1 activity and hBD-3 production by increasing prostaglandin D(2) release from keratinocytes. Itraconazole Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
5 These results suggest that itraconazole and terbinafine hydrochloride may enhance c-Fos expression and phosphorylation, activator protein-1 activity and hBD-3 production by increasing prostaglandin D(2) release from keratinocytes. Itraconazole Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens