Title : KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation.

Pub. Date : 2010 Nov-Dec

PMID : 20870034






5 Functional Relationships(s)
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Protein Name
Organism
1 In isolated PA, KMUP-1 and simvastatin (0.1-100 muM) inhibited 5-HT (10 muM)-induced PA constriction. Simvastatin latexin Homo sapiens
2 In isolated PA, KMUP-1 and simvastatin (0.1-100 muM) inhibited 5-HT (10 muM)-induced PA constriction. Simvastatin latexin Homo sapiens
3 In pulmonary arterial smooth muscle cells (PASMCs), KMUP-1 (1-100 muM) and simvastatin (10 muM) inhibited 5-HT-induced cell migration and proliferation and KMUP-1 (1-100 muM) inhibited 5-HT-induced Ca2+ influx. Simvastatin latexin Homo sapiens
4 In pulmonary arterial smooth muscle cells (PASMCs), KMUP-1 (1-100 muM) and simvastatin (10 muM) inhibited 5-HT-induced cell migration and proliferation and KMUP-1 (1-100 muM) inhibited 5-HT-induced Ca2+ influx. Simvastatin latexin Homo sapiens
5 Similar to Y27632, KMUP-1 (1-100 muM) inhibited 5-HT-induced RhoA/ROCK expression, while KMUP-1, Y27632 and simvastatin at 10 muM inhibited 5-HT-induced 5-HTT expression and KMUP-1 inhibited 5-HT-induced phosphorylation of AKT and ERK1/2 in PASMCs. Simvastatin latexin Homo sapiens