Title : Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons.

Pub. Date : 2010 Dec 15

PMID : 20870010






4 Functional Relationships(s)
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1 In contrast to the ability of chronic NGF to increase peptide content, acute exposure of sensory neurons to 100 ng/mL NGF augments capsaicin-evoked release of CGRP without affecting the content of CGRP. Capsaicin calcitonin related polypeptide alpha Homo sapiens
2 In contrast, the NGF-induced increase in capsaicin-evoked release of CGRP is blocked by the protein kinase C (PKC) inhibitor, BIM and the Src family kinases inhibitor, PP2. Capsaicin calcitonin related polypeptide alpha Homo sapiens
3 These data demonstrate that different signaling pathways mediate the alterations in expression of CGRP by chronic NGF and the acute actions of the neurotrophin to augment capsaicin-evoked release of CGRP in the absence of a change in the content of the peptide. Capsaicin calcitonin related polypeptide alpha Homo sapiens
4 These data demonstrate that different signaling pathways mediate the alterations in expression of CGRP by chronic NGF and the acute actions of the neurotrophin to augment capsaicin-evoked release of CGRP in the absence of a change in the content of the peptide. Capsaicin calcitonin related polypeptide alpha Homo sapiens