Pub. Date : 2010 Dec 15
PMID : 20863785
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In static culture, simvastatin potentiated the TNFalpha-induced increase in VCAM-1 and ICAM-1 mRNA but not total protein at 24 h. Mevalonate, a precursor to cholesterol biosynthesis, eliminated the effect of simvastatin. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 2 | In static culture, simvastatin potentiated the TNFalpha-induced increase in VCAM-1 and ICAM-1 mRNA but not total protein at 24 h. Mevalonate, a precursor to cholesterol biosynthesis, eliminated the effect of simvastatin. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 3 | We conclude that simvastatin enhances VCAM-1 and ICAM-1 gene expression in TNFalpha-activated endothelial cells through inhibition of HMG-CoA reductase. | Simvastatin | tumor necrosis factor | Homo sapiens |