Pub. Date : 2010 Dec 15
PMID : 20863785
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, the effect of simvastatin on vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression was evaluated in human abdominal aortic endothelial cells (HAAEC) conditioned with various levels of laminar wall shear stress with or without tumor necrosis factor alpha (TNFalpha). | Simvastatin | vascular cell adhesion molecule 1 | Homo sapiens |
| 2 | In this study, the effect of simvastatin on vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression was evaluated in human abdominal aortic endothelial cells (HAAEC) conditioned with various levels of laminar wall shear stress with or without tumor necrosis factor alpha (TNFalpha). | Simvastatin | vascular cell adhesion molecule 1 | Homo sapiens |
| 3 | In static culture, simvastatin potentiated the TNFalpha-induced increase in VCAM-1 and ICAM-1 mRNA but not total protein at 24 h. Mevalonate, a precursor to cholesterol biosynthesis, eliminated the effect of simvastatin. | Simvastatin | vascular cell adhesion molecule 1 | Homo sapiens |
| 4 | A shear stress of 12.5 dyn/cm2 eliminated the increase in VCAM-1 by simvastatin, while 25 dyn/cm2 was needed for ICAM-1. | Simvastatin | vascular cell adhesion molecule 1 | Homo sapiens |
| 5 | We conclude that simvastatin enhances VCAM-1 and ICAM-1 gene expression in TNFalpha-activated endothelial cells through inhibition of HMG-CoA reductase. | Simvastatin | vascular cell adhesion molecule 1 | Homo sapiens |
| 6 | High levels of laminar shear stress prevented the upregulation of VCAM-1 and ICAM-1 by simvastatin suggesting that an induction of cell adhesion molecules by statins may not occur in endothelial cells exposed to shear stress from blood flow. | Simvastatin | vascular cell adhesion molecule 1 | Homo sapiens |