Title : Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase.

Pub. Date : 2010 Nov-Dec

PMID : 20863570






1 Functional Relationships(s)
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1 This is particularly true for mast cells which play a key regulatory role in allergy and inflammation through activation via high-affinity IgE receptors (FceRI) leading to activation of signaling cascades and subsequent release of histamine and other pro-inflammatory mediators. Histamine Fc epsilon receptor Ia Homo sapiens