Title : Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.

Pub. Date : 2010 Dec 15

PMID : 20862710






3 Functional Relationships(s)
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1 Low-dose ATO produced reactive oxygen species (ROS), and activated the p38 MAPK, Akt, and ERK1/2 pathways at different time points within 60 min. Arsenic Trioxide AKT serine/threonine kinase 1 Homo sapiens
2 Inhibiting the activation of Akt and ERK1/2, but not p38 MAPK, decreased the ATO-induced expression of cyclin D1 protein. Arsenic Trioxide AKT serine/threonine kinase 1 Homo sapiens
3 This study reports for the first time that p38 MAPK/Akt/ERK1/2 activation is required for the protein stabilization of CDC6 in addition to cyclin D1 in ATO-induced cell proliferation and cell cycle modulation from G1 to S phase. Arsenic Trioxide AKT serine/threonine kinase 1 Homo sapiens