Title : Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice.

Pub. Date : 2010 Sep 13

PMID : 20856928






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MPs(Shh+)-mediated effects on flow recovery and NO production were completely prevented when Shh signalling was inhibited by cyclopamine. cyclopamine sonic hedgehog Mus musculus
2 MPs(Shh+)-mediated effects on flow recovery and NO production were completely prevented when Shh signalling was inhibited by cyclopamine. cyclopamine sonic hedgehog Mus musculus
3 In aorta, MPs(Shh+) increased activation of eNOS/Akt pathway, and VEGF expression, being inhibited by cyclopamine. cyclopamine sonic hedgehog Mus musculus
4 By contrast, in muscles, MPs(Shh+) enhanced eNOS expression and phosphorylation and decreased caveolin-1 expression, but cyclopamine prevented only the effects of MPs(Shh+) on eNOS pathway. cyclopamine sonic hedgehog Mus musculus