Title : Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-κB pathway activation.

Pub. Date : 2010 Dec 1

PMID : 20854900






1 Functional Relationships(s)
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1 These results, for the first time, reveal that DEHP induces apoptosis in hepatocytes via the activation of the ERK/NF-kappaB signaling pathway, in which calcium ions and hydrogen peroxide act as the pivotal mediators of the apoptotic signaling. Calcium mitogen-activated protein kinase 1 Homo sapiens