Title : Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF.

Pub. Date : 2011 Jan 10

PMID : 20851742






3 Functional Relationships(s)
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1 Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. Simvastatin glial cell derived neurotrophic factor Rattus norvegicus
2 Results show that the simvastatin-treated animals showed significantly better locomotor function recovery, better electrophysiological outcome, less myelin loss, and higher expression of BDNF and GDNF. Simvastatin glial cell derived neurotrophic factor Rattus norvegicus
3 These findings suggest that simvastatin treatment starting 1 day after SCI can significantly improve locomotor recovery, and this neuroprotective effect may be related to the upregulation of BDNF and GDNF. Simvastatin glial cell derived neurotrophic factor Rattus norvegicus