Title : Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide.

Pub. Date : 2010 Aug 19

PMID : 20847952






5 Functional Relationships(s)
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1 The appearance and resolution of gammaH2AX foci in murine embryonic fibroblast cell lines, wild type and null for DNA topoisomerase IIbeta, was measured after exposure to ionising radiation (IR) or etoposide. Etoposide H2A.X variant histone Mus musculus
2 Etoposide triggered the formation of topoisomerase II-DNA adducts and the phosphorylation of histone H2AX, the gammaH2AX foci appeared more slowly with etoposide than with IR. Etoposide H2A.X variant histone Mus musculus
3 Etoposide triggered the formation of topoisomerase II-DNA adducts and the phosphorylation of histone H2AX, the gammaH2AX foci appeared more slowly with etoposide than with IR. Etoposide H2A.X variant histone Mus musculus
4 Etoposide triggered the formation of topoisomerase II-DNA adducts and the phosphorylation of histone H2AX, the gammaH2AX foci appeared more slowly with etoposide than with IR. Etoposide H2A.X variant histone Mus musculus
5 Etoposide triggered the formation of topoisomerase II-DNA adducts and the phosphorylation of histone H2AX, the gammaH2AX foci appeared more slowly with etoposide than with IR. Etoposide H2A.X variant histone Mus musculus