Title : Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance.

Pub. Date : 2010 Oct 15

PMID : 20844194






1 Functional Relationships(s)
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1 In this study, we report the development of a long-lasting autoactive human mutant TGF-beta1/Fc fusion protein that acts in conjunction with rapamycin to inhibit T cell proliferation and induce the de novo generation of Foxp3(+) Treg in the periphery, while at the same time inhibiting IL-6-mediated Th17 cell differentiation. Sirolimus interleukin 6 Homo sapiens