Title : Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.

Pub. Date : 2010 Oct 15

PMID : 20841379






2 Functional Relationships(s)
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1 Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics. Phosphatidylinositol 4,5-Diphosphate thymoma viral proto-oncogene 1 Mus musculus
2 Using this mutant, we show that Rac controls the plasma membrane localisation of PIP5Kbeta and thereby the localised synthesis of PtdIns(4,5)P2 required to induce neurite retraction. Phosphatidylinositol 4,5-Diphosphate thymoma viral proto-oncogene 1 Mus musculus