Pub. Date : 2010 Dec 1
PMID : 20840854
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 2 | A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 3 | This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 4 | This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |