Pub. Date : 2010 Sep 3
PMID : 20838437
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors. | Lovastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Lovastatin attenuated ligand-induced receptor activation and downstream signaling through the PI3K/AKT pathway. | Lovastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In this study, we have shown that lovastatin inhibits ligand-induced VEGFR-2 activation through inhibition of receptor internalization and also inhibits VEGF activation of AKT in human umbilical vein endothelial cells (HUVEC) and H28 MM cells employing immunofluorescence and Western blotting. | Lovastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Combinations of lovastatin and a VEGFR-2 inhibitor showed more robust AKT inhibition than either agent alone in the H28 MM cell line. | Lovastatin | AKT serine/threonine kinase 1 | Homo sapiens |