Pub. Date : 2010 Dec
PMID : 20832472
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Incubation of MAO-B with 2-phenylethylamine, an endogenous trace amine and MAO-B substrate, resulted in a progressive loss of enzyme activity, increased enzyme mass, distinct spectral changes and, as was observed with tranylcypromine, a parallel increase in high affinity binding of [(3)H]2-BFI. | 2-(2-benzofuranyl)-2-imidazoline | monoamine oxidase B | Homo sapiens |
| 2 | Kinetic studies of the mechanism by which 2-BFI inhibits MAO-B activity suggested binding of 2-BFI, at micromolar concentrations, to a site distinct from the active site on at least two forms of the pure enzyme, probably corresponding to oxidised and reduced enzyme states. | 2-(2-benzofuranyl)-2-imidazoline | monoamine oxidase B | Homo sapiens |
| 3 | Kinetic studies of the mechanism by which 2-BFI inhibits MAO-B activity suggested binding of 2-BFI, at micromolar concentrations, to a site distinct from the active site on at least two forms of the pure enzyme, probably corresponding to oxidised and reduced enzyme states. | 2-(2-benzofuranyl)-2-imidazoline | monoamine oxidase B | Homo sapiens |
| 4 | Studies with mutant enzymes revealed a pattern of changes consistent with binding of 2-BFI to the substrate entrance channel of human MAO-B. | 2-(2-benzofuranyl)-2-imidazoline | monoamine oxidase B | Homo sapiens |