Title : Contribution of fructose-6-phosphate to glucocorticoid activation in the endoplasmic reticulum: possible implication in the metabolic syndrome.

Pub. Date : 2010 Oct

PMID : 20826560






3 Functional Relationships(s)
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1 Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) depends on hexose-6-phosphate dehydrogenase (H6PD), which physically interacts with 11beta-HSD1 at the luminal surface of the endoplasmic reticulum (ER) membrane and generates reduced nicotinamide adenine dinucleotide phosphate for the reduction of glucocorticoids. NADP hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens
2 Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) depends on hexose-6-phosphate dehydrogenase (H6PD), which physically interacts with 11beta-HSD1 at the luminal surface of the endoplasmic reticulum (ER) membrane and generates reduced nicotinamide adenine dinucleotide phosphate for the reduction of glucocorticoids. NADP hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens
3 Our findings indicate that the mechanisms of F6P and G6P transport across the ER membrane are distinct and provide evidence that F6P is converted to G6P in the ER lumen, thus yielding substrate for H6PD-dependent reduced nicotinamide adenine dinucleotide phosphate generation. NADP hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens